Table 4. Serologic outcomes of pregnant women with active syphilis treated with amoxicillin or ampicillin, Japan, 2010–2018, by delivery, 6 months after treatment, and 1 year after treatment*.
| Patient group | No./total (%) with >4-fold decrement in RPR titer |
|||
|---|---|---|---|---|
| By delivery | 6 months after treatment | 1 year after treatment |
||
| All | 35/71 (49) | 41/77 (53) | 46/56 (82) | |
| Live birth without CS diagnosis | 27/54 (50) | 29/54 (54) | 31/39 (80) | |
| CS cases† | 5/13 (39) | 6/15 (40) | 9/11 (82) | |
| Early syphilis | 15/26 (58) | 20/30 (67) | 21/23 (91) | |
| Late syphilis | 20/45 (44) | 21/47 (45) | 25/33 (76) | |
| Amoxicillin | 27/58 (47) | 32/63 (51) | 36/44 (82) | |
| Ampicillin | 8/13 (62) | 9/14 (64) | 10/12 (83) | |
| Japanese | 34/66 (52) | 39/72 (54) | 44/52 (85) | |
| Non-Japanese | 1/5 (20) | 2/5 (40) | 2/4 (50) | |
| Started syphilis treatment >60 days before delivery | 32/55 (58) | 32/55 (58) | 35/43 (81) | |
| Started syphilis treatment <60 days before delivery | 0 | 5/17 (29) | 6/8 (75) |
|
*CS, congenital syphilis; RPR, rapid plasma reagin. †CS cases include newborns with CS diagnoses, miscarriages, and stillbirths.