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Mean Isoniazid Pharmacokinetic Data, by Dose and Arm
| Isoniazid-Resistant Tuberculosis |
Control Subjects | |||
|---|---|---|---|---|
| 5 mg/kg | 10 mg/kg | 15 mg/kg | 5 mg/kg | |
| Cmax, μg/ml | 5.44 | 9.41 | 17.1 | 5.13 |
| AUC0–24, μg · h/ml | 19.3 | 45.7 | 67.7 | 15.1 |
| CL/F, L/h | 24.3 | 18.0 | 14.2 | 26.5 |
Definition of abbreviations: AUC0–24 = area under the concentration–time curve over 24 hours; CL/F = oral clearance; Cmax = maximum concentration.
