Table 1.
Demographic, Clinical, and Hemodynamic Characteristics by Self-reported Race/Ethnicity
| Variable | PAH Biobank | AHN Cohort | |||||
|---|---|---|---|---|---|---|---|
| Non-Hispanic White (n = 1,039) | Non-Hispanic AA (n = 158) | Hispanic (n = 129) | Non-Hispanic White (n = 656) | AA (n = 97) | Hispanic (n = 69) | ||
| Age, yr | 53 ± 18 | 52 ± 17 | 42 ± 16 | 52 ± 16 | 51 ± 14 | 36 ± 11 | |
| Sex, F | 786 (76) | 134 (85) | 111 (86) | 523 (79) | 90 (93) | 60 (87) | |
| Prostacyclin analogs | 284 (27) | 34 (22) | 24 (19) | 87 (13) | 19 (20) | 3 (4) | |
| Ancestry estimates*, % | |||||||
| African | 0.01 | 0.82 | 0.07 | 0.02 | 0.82 | 0.02 | |
| European | 0.97 | 0.16 | 0.58 | 0.97 | 0.17 | 0.50 | |
| NA | 0.02 | 0.02 | 0.36 | 0.02 | 0.01 | 0.47 | |
| mRAP, mm Hg | 9.27 ± 5.65 | 10.2 ± 5.91 | 9.87 ± 7.97 | 8.66 ± 5.29 | 10.41 ± 8.04 | 10.09 ± 12.34 | |
| mPAP, mm Hg | 52.2 ± 14.1 | 47.7 ± 13.6 | 56.1 ± 15.8 | 51.2 ± 16.9 | 45.8 ± 15.2 | 66.0 ± 20.0 | |
| PCWP, mm Hg | 10.1 ± 3.99 | 10.3 ± 3.79 | 9.34 ± 3.34 | 10.52 ± 5.22 | 10.91 ± 4.48 | 8.94 ± 4.16 | |
| Cardiac index, L/min/m2 | 2.52 ± 1.26 | 2.34 ± 0.93 | 2.12 ± 0.72 | 2.61 ± 1.34 | 2.39 ± 0.69 | 3.17 ± 1.41 | |
| PVR, WU | 10.93 ± 6.54 | 10.2 ± 6.40 | 13.6 ± 8.12 | 10.91 ± 6.80 | 8.58 ± 5.25 | 14.32 ± 9.55 | |
| 6MWD, m | 356 ± 138 | 331 ± 114 | 378 ± 99 | 353 ± 128 | 297 ± 107 | 311 ± 96 | |
Definition of abbreviations: 6MWD = 6-minute-walk distance; AA = African American; AHN = Allegheny Health Network; AIMs = ancestry-informative markers; mPAP = mean pulmonary arterial pressure; mRAP = mean right atrial pressure; NA = Native American; PAH = pulmonary arterial hypertension; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; WU = Wood units.
Continuous data are presented as mean ± SD, and categorical variables are presented as n (%) unless otherwise specified.
*
Ancestry estimates were generated using AIMs input into STRUCTURE using HapMap reference populations.