Table 2.
Any Day Ancillary Use for Overall Maximum PALICC ARDS Severity in the 72-Hour Study Period
| Adjunctive Therapy, Any Day (n = 624) | NIV (n = 66) | Mild (n = 124) | Moderate (n = 178) | Severe (n = 256) | All (n = 624) | P Value |
|---|---|---|---|---|---|---|
| cNMB | 0 (0.0) | 16 (12.9) | 51 (28.7) | 129 (50.4) | 196 (31.4) | <0.001 |
| Corticosteroids for PARDS | 6 (9.1) | 5 (4.0) | 20 (11.2) | 33 (12.9) | 64 (10.3) | 0.059 |
| iNO | 1 (1.5) | 2 (1.6) | 11 (6.2) | 67 (26.2) | 81 (13.0) | <0.001 |
| Prone positioning | 1 (1.5) | 1 (0.8) | 14 (7.9) | 47 (18.4) | 63 (10.1) | <0.001 |
| HFOV | 0 (0.0) | 1 (0.8) | 1 (0.6) | 56 (21.9) | 58 (9.3) | <0.001 |
| ECMO | 0 (0.0) | 1 (0.8) | 2 (1.1) | 16 (6.3) | 19 (3.0) | 0.002 |
Definition of abbreviations: ARDS = acute respiratory distress syndrome; cNMB = continuous neuromuscular blockade; ECMO = extracorporeal membrane oxygenation; HFOV = high-frequency oscillatory ventilation; iNO = inhaled nitric oxide; NIV = noninvasive ventilation; PALICC = Pediatric Acute Lung Injury Consensus Conference; PARDS = pediatric acute respiratory distress syndrome.
Results are presented as n (%). Subjects were grouped into worse severity in the first 72 hours of PARDS diagnosis.