Table 49.2.
Bone marrow pathologies associated with human viral infections.
| Pathology | Virus | Comments |
|---|---|---|
| Pancytopenia | EBV | Self-resolving |
| HCV | Affected by medication | |
| Aplastic anemia | Parvovirus B19 | Driven by infection of erythroid progenitors |
| EBV, CMV, VZV, HHV, HIV, HAV, and HCV | Driven by a strong antiviral T cell response and ensuing cytokine production | |
| Dengue | Mechanism unknown | |
| HLH | CMV | Driven by the ensuing antiviral immune response rather than the virus itself |
| Parvovirus B19 | ||
| Dengue | ||
| HAV | ||
| HIV (acute) | ||
| Lymphoproliferative disorders and malignancies | EBV | Infectious mononucleosis and chronic active EBV disease |
| HCV | Acute myeloid leukemia, primary myelodysplastic syndrome |
Table reproduced from Pascutti MF, Erkelens MN, Nolte MA. Impact of viral infections on hematopoiesis: from beneficial to detrimental effects on Bone marrow output. Front Immunol 2016;7:364. Reprinted under https://creativecommons.org/licenses/by/4.0/.