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. 2020 May 22;10:681. doi: 10.3389/fonc.2020.00681

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Copyright © 2020 Li, Cai, Tsai and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visualization of the protein-protein interaction (PPI) network and the candidate hub genes. (A) PPI network of the genes between DEG lists and two co-expression modules. The blue nodes represent the genes. Edges indicate interaction associations between nodes. (B) Identification of the hub genes from the PPI network using maximal clique centrality (MCC) algorithm. Edges represent the protein-protein associations. The red nodes represent genes with a high MCC sores, while the yellow node represent genes with a low MCC sore.