Figure 6.

AP-Cav prevents enhanced pulmonary arterial constriction in response to KCl after CH. (A) Vasoconstrictor (% baseline inner diameter) and (B) vessel wall [Ca²⁺]_i (fura-2, F₃₄₀/F₃₈₀) responses to KCl in pressurized, Ca²⁺-permeabilized, endothelium-disrupted pulmonary arteries from CH and control rats in the presence of AP-Cav or AP-Scramb (10 μM each). Vessel wall [Ca²⁺]_i was not different between groups or treatments, confirming Ca²⁺-clamp conditions. Values are means ± SE of n = 5–6 rats/group. *P < 0.05 versus control AP-Scramb. ^#P < 0.05 CH AP-Cav versus CH AP-Scramb.