Figure 7.

CH-induced increases in basal and KCl-stimulated O₂⁻ production in pressurized pulmonary arteries are prevented by AP-Cav. DHE fluorescence (AU) under basal conditions and after administration of KCl (60 mM beginning at 1 min) in pressurized, Ca²⁺-permeabilized, endothelium-disrupted pulmonary arteries from control and CH rats. Values are means ± SE of n = 4–5 rats/group. *P < 0.05 versus the respective control group at all time points. ^#P < 0.05 CH AP-Cav versus CH AP-Scramb at all time points. ^†P < 0.05 versus CH AP-Scramb before KCl administration.