Figure 8.

Loss of membrane cholesterol facilitates EGF (epidermal growth factor)-dependent vasoconstriction after CH. (A) Vasoconstrictor and (B) vessel wall [Ca²⁺]_i (F₃₄₀/F₃₈₀) responses to EGF in pressurized, endothelium-disrupted, nonpermeabilized pulmonary arteries from CH and control rats. (C and D) Vasoconstrictor responses to EGF in arteries from control (C) and CH rats (D) in the presence of supplemental cholesterol or vehicle. Values are means  ± SE of n = 4–5/group. *P < 0.05 versus control or vehicle.