Table 1.
Cognitive and Functional Outcomes in CCR5-Δ32 Carriers versus Non-carriers
| Non-carriers | CCR5-Δ32 Carriers | p | |
|---|---|---|---|
| At Admission | |||
| N | 328 | 68 | |
| Cognitive Scores | |||
| Computerized total cognitive score (SD) | 92.1 (15) | 94.2 (13) | 0.400 |
| Memory score (SD) | 88 (9.1) | 91.5 (16.4) | 0.258 |
| Executive function score (SD) | 93.8 (14.4) | 95.7 (14) | 0.421 |
| Visuospatial score (SD) | 97.8 (18.2) | 101.5 (16.4) | 0.205 |
| Verbal functioning score (SD) | 89.6 (22.8) | 85.6 (24.9) | 0.301 |
| Attention score (SD) | 92.8 (19.3) | 96.7 (16.4) | 0.208 |
| MoCA score (SD) | 23.6 (3.5) | 24.5 (3.1) | 0.099 |
| 3 Months post Stroke | |||
| N | 314 | 52 | |
| Functional Scores | |||
| Poor functional outcome (modified Rankin scale >2), n (%) | 160 (51) | 18 (34.6) | 0.029 |
| Poor functional outcome (modified Rankin scale >3), n (%) | 81 (25.8) | 7 (13.5) | 0.054 |
| FIM (total) (SD) | 119.8 (12) | 122.4 (735) | 0.042 |
| 6 Months post Stroke | |||
| N | 338 | 63 | |
| Cognitive Scores | |||
| Computerized total cognitive score (SD) | 94.1 (13.0) | 97 (11.8) | 0.106 |
| Memory score (SD) | 93.3 (17.4) | 95.6 (17.4) | 0.347 |
| Executive function score (SD) | 95.3 (12.7) | 98.3 (11.4) | 0.089 |
| Visuospatial score (SD) | 96.7 (17.7) | 97.7 (17.4) | 0.698 |
| Verbal functioning score (SD) | 90.4 (21.7) | 92.2 (21.4) | 0.544 |
| Attention score (SD) | 94.6 (16.1) | 100.4 (11.9) | 0.002 |
| MoCA score (SD) | 24.9 (3.7) | 25.9 (2.7) | 0.017 |
| Functional Scores | |||
| NIHSS (SD) | 0.7 (1.3) | 0.4 (0.9) | 0.08 |
| Delta NIHSS from admission to 6 months | 2.2 (2.9) | 1.4 (1.9) | 0.024 |
| Poor functional outcome (modified Rankin scale >2), n (%) | 66 (19.5) | 7 (11.1) | 0.165 |
| Poor functional outcome (modified Rankin scale > 3), n (%) | 26 (7.7) | 0 | 0.052 |
| 1 Year post Stroke | |||
| N | 328 | 68 | |
| Cognitive Scores | |||
| Computerized total cognitive score (SD) | 95.5 (13.4) | 98.5 (10.2) | 0.047 |
| Memory score (SD) | 96.4 (16.5) | 100.6 (13.4) | 0.033 |
| Executive function score (SD) | 96.9 (12.9) | 98 (12.2) | 0.533 |
| Visuospatial score (SD) | 99.6 (17.8) | 98.3 (16.9) | 0.615 |
| Verbal functioning score (SD) | 89.1 (23.6) | 95.9 (17.5) | 0.011 |
| Attention score (SD) | 96.6 (14.7) | 100.4 (11.3) | 0.024 |
| MoCA score (SD) | 23.7 (4.2) | 24.5 (3.1) | 0.017 |
| Functional Scores | |||
| NIHSS 1 year post stroke (SD) | 0.7 (1.6) | 0.4 (0.9) | 0.08 |
| Delta NIHSS from admission to 1 year (SD) | 2.4 (3.1) | 1.4 (2.1) | 0.007 |
| Poor functional outcome (modified Rankin scale >2), n (%) | 40 (12.2) | 10 (14.7) | 0.594 |
| Poor functional outcome (modified Rankin scale >3), n (%) | 14 (4.2) | 4 (5.8) | 0.474 |
| 2 Years post Stroke | |||
| N | 285 | 49 | |
| Cognitive Scores | |||
| MoCA score (SD) | 25 (3.9) | 26.7 (2.4) | <0.001 |
| Functional Scores | |||
| NIHSS (SD) | 0.7 (1.3) | 0.3 (0.9) | 0.032 |
| Delta NIHSS from admission to 2 years | 2.2 (2.9) | 1.3 (2.1) | 0.059 |
| Poor functional outcome (modified Rankin scale >2), n (%) | 46 (16.2) | 9 (18.4) | 0.673 |
| Poor functional outcome (modified Rankin scale >3), n (%) | 23 (8.1) | 3 (6.2) | 0.748 |
Entries are mean (SD) or n and %, as indicated. Significant results are shown in bold (p < 0.05). SD, standard deviation; NIHSS, National Institutes of Health stroke scale; MoCA, Montreal cognitive assessment; FIM, functional independence measure.