KEY RESOURCES TABLE.

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-GLAST ASCA microbead kit	Miltenyi Biotec	130-095-826
Anti-CD11b microbead kit	Miltenyi Biotec	120-005-959
Mouse Neuronal isolation kit	Miltenyi Biotec	130-0987-752
Mouse-CD11b-FITC	Miltenyi Biotec	130-098-085
Mouse NCAM-1/CD56 APC-conjugated	R&D	FAB7820A
Rat-GFAP	Thermo Fisher	13-0300
Rabbit-IBA-1	Wako Chemicals	019-19741
Rabbit-NeuN	Abcam	ab177487
Rabbit-pCREB	Cell Signaling	9197
Rabbit-CREB	Cell Signaling	9198
Rabbit-JNK1/JNK2	Cell Signaling	9926
Rabbit p38 MAPK	Cell Signaling	9926
Rabbit-GAP43	Abcam	ab75810
Rabbit-(MAP3K12) DLK	Abcam	ab37996
Erk p42/p44	Cell Signaling	9926
Anti-mouse Ly6G	Biolegend	127625
Anti-mouse Ly6C	Biolegend	128015
Bacterial and Virus Strains
AAV5-hU6-shCCR5-EF1-GFP	Zhou et al., 2016	N/A
AAV5-hU6-dsRED-EF1-GFP	Zhou et al., 2016	N/A
AAV5-hSYN1-mCherry-U6-m-MAP3K12-shRNA	Vector Biolabs	N/A
Chemicals, Peptides, and Recombinant Proteins
Maraviroc	Selleckchem	S2003
Critical Commercial Assays
ViewRNA ISH FISH kit	Affymetrix	QVT-0012
Experimental Models: Organisms/Strains
Thy-YFP-H	JAX	Stock No: 003782
Oligonucleotides
CCR5 FISH probe	Affymetrix	VX-06; VB1-18681-VT
TUBB3 FISH probe	Affymetrix	VX-06;VB6-16302-VT
CX3CR1 FISH probe	Affymetrix	VX-06; VB6-17362-VT
CCR5 (NM_00917.5) forward primer 5′TGCTGCCTAAACCCTGTCAT3′ and reverse primer 5′CGATCAGGATTGTCTTGCTGGA3′	Thermo fisher	N/A
GAPDH forward primer AGGTCGGTGTGAACGGATTTG reverse primer TGTAGACCATGTAGTTGAGGT	Thermo fisher	N/A
UBC forward primer CCAAGAAGGTCAAACAGGAAGA reverse primer CCCATCACACCCAAGAACAA	Thermo fisher	N/A
GFAP Forward primer CACGAACGAGTCCCTAGAGC Reverse primer GTAGGTGGCCGATCTCGATGT	Thermo fisher	N/A
IBA-1 Forward primer GGACAGACTGCCAGCCTAAG Reverse primer GACGGCAGATCCTCATCATT	Thermo fisher	N/A
PSD95 Forward primer CCCCAACATGGACTGTCTCT Reverse primer ACTCCATCTCCCCCTCTGTT	Thermo fisher	N/A
Software and Algorithms
Heatmap	Custom	Li et.al., 2010