Table 3.
Copy Number Loss of PTEN and CDKN2A and Immunoreactive Scores in Chordomas
| Copy Number Variation | Conventional Chordoma (n=26) | Chondroid Chordoma (n=16) | Statistical Value (Chi-Square or t value) | P value |
|---|---|---|---|---|
| PTEN | ||||
| Intact (n) | 8 (30.8%) | 9 (56.3%) | 3.051a | 0.218 |
| Heterozygous loss (n) | 15 (57.7%) | 5 (31.2%) | ||
| Homozygous loss (n) | 3 (11.5%) | 2 (12.5%) | ||
| CDKN2A | ||||
| Intact (n) | 10 (38.5%) | 4 (25.0%) | 0.973a | 0.615 |
| Heterozygous loss (n) | 13 (50.0%) | 9 (56.3%) | ||
| Homozygous loss (n) | 3 (11.5%%) | 3 (18.7%) | ||
| PTEN immunoreactive score (mean ± SD) | 6.85 ± 3.82 | 7.75 ± 4.19 | 0.718b | 0.477 |
| CDKN2A immunoreactive score (mean ± SD) | 7.46 ± 3.73 | 6.44 ± 4.58 | 0.792b | 0.433 |
Notes: aChi-square test; bIndependent-sample t test.