Figure 1. The tryptophan metabolic pathway is highly regulated in the host response to TB disease and chemotherapy-mediated bacterial clearance.

(A) Differences in metabolic pathway activity (21) in persons from the country of Georgia with active TB disease at the time of diagnosis (n = 89) versus controls without active TB disease (n = 57). (B) Changes in metabolic pathway activity in persons from Georgia over 4 months of treatment for drug-susceptible TB (DS-TB) disease with directly observed therapy. The horizontal bars show the magnitude of the –log(P value) for pathway enrichment in each pathway.