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. 2020 May 21;5(10):e136653. doi: 10.1172/jci.insight.136653

Figure 6. HA-stem response hindered by particulate display of antigen.

Figure 6

C57BL/6 mice (n = 5 mice per group) were vaccinated intramuscularly with high or low doses of HA-ferritin (5 or 0.5 μg) or a molar equivalent of soluble HA (3.8 or 0.38 μg). All vaccines were adjuvanted with AddaVax. Serum IgG titers against stem HA (A) or full-length HA (B) were measured by ELISA at 7, 14, 28, or 56 days after vaccination. Data represent mean ± SD and are representative of 1 of 2 independent experiments. The dashed line indicates detection cutoff (1:100 dilution).