Fig 6. Liver toxicity enzyme tests in vehicle and TNAP treated FGFR2^C342Y/+ mice.

Alanine amino transferase (ALT) and aspartate amino transferase (AST) liver enzymes were measured in serum of vehicle and treated C57BL/6 mice. When compared by groups, no differences were seen between FGFR2^+/+ and FGFR2^C342Y/+ vehicle treated mice. Treatment decreased serum ALT (A) and increased serum AST (B) in FGFR2^C342Y/+ mice. Linear regression analyses showed a significant reverse correlation (r = -.73; 95% CI of -.898 to -.361, p < .005) between AP and ALT enzyme levels in FGFR2^C342Y/+ mice (C). No correlation was found between AP and AST enzyme levels in FGFR2^C342Y/+ mice (D). No correlations were found between ALT (E) or AST (F) enzyme levels and body weight.