Table 4. Cranial bone volume, density and mineral content in control and TNAP treated BALB/c and C57BL/6 mice.
| Genotype | Treatment | Cranial Bone | Bone Mineral Content (mg) | Bone Mineral Density (mg/cc) | Tissue Mineral Content (mg) | Tissue Mineral Density (mg/cc) | Bone Volume Fraction | |
|---|---|---|---|---|---|---|---|---|
| BALB/c | FGFR2+/+ | vehicle | Frontal | 0.035 +/- 0.004 | 405 +/- 14* | 0.028 +/- 0.007* | 692 +/- 14* | 0.41 +/- 0.03* |
| BALB/c | FGFR2C342Y/+ | vehicle | Frontal | 0.031 +/- 0.008 | 361 +/- 63 | 0.020 +/- 0.006# | 671 +/- 18 | 0.36 +/- 0.00 |
| BALB/c | FGFR2C342Y/+ | TNAP | Frontal | 0.035 +/- 0.005 | 401 +/- 26# | 0.026 +/- 0.015# | 683 +/- 29 | 0.42 +/- 0.06# |
| BALB/c | FGFR2+/+ | vehicle | Parietal | 0.034 +/- 0.004 | 405 +/- 12 | 0.023 +/- 0.005 | 693 +/- 15* | 0.43 +/- 0.03* |
| BALB/c | FGFR2C342Y/+ | vehicle | Parietal | 0.031 +/- 0.007 | 396 +/- 39 | 0.020 +/- 0.005 | 669 +/- 24 | 0.36 +/- 0.06 |
| BALB/c | FGFR2C342Y/+ | TNAP | Parietal | 0.034 +/- 0.006 | 403 +/- 27 | 0.025 +/- 0.012 | 691 +/- 36 | 0.42 +/- 0.07# |
| C57BL/6 | FGFR2+/+ | vehicle | Frontal | 0.017 +/- 0.003 | 245 +/- 25* | 0.006 +/- 0.001* | 570 +/- 18* | 0.12 +/- 0.01* |
| C57BL/6 | FGFR2C342Y/+ | vehicle | Frontal | 0.013 +/- 0.002 | 209 +/- 25 | 0.004 +/- 0.001 | 519 +/- 26 | 0.10 +/- 0.01 |
| C57BL/6 | FGFR2C342Y/+ | TNAP | Frontal | 0.016 +/- 0.004 | 225 +/- 30 | 0.004 +/- 0.001 | 553 +/- 40 | 0.11 +/- 0.01 |
| C57BL/6 | FGFR2+/+ | vehicle | Parietal | 0.015 +/- 0.001 | 237 +/- 19 | 0.005 +/- 0.001 | 590 +/- 13* | 0.12 +/- 0.02* |
| C57BL/6 | FGFR2C342Y/+ | vehicle | Parietal | 0.012 +/- 0.003 | 217 +/- 18 | 0.004 +/- 0.001 | 558 +/- 36 | 0.10 +/- 0.01 |
| C57BL/6 | FGFR2C342Y/+ | TNAP | Parietal | 0.013 +/- 0.004 | 232 +/- 42 | 0.004 +/- 0.001 | 575 +/- 32 | 1.11 +/- 0.01 |
* p value < 0.01 between genotypes.
# p value < 0.01 between treatment groups.