Table 1. Cost-effectiveness model parameters, with uncertainty ranges.
| Input parameter | Value | Sensitivity |
|---|---|---|
| Fully vaccinate population | 146,255 [28] | - |
| Vaccination campaign coverage (%) | 65% [47] | 40 [63] to 80% [49] |
| Overall protective effectiveness (%) | 39% [23] | 34.3 to 43.3 [23–25] |
| Duration of vaccine protection (years) | 1 [29] | 0.6 to 5 [Assumption] |
| Incidences (cases/1000) | 4.3 [40] | 2 to 11.34 [7] |
| Case Fatality Ratio (cases/1000) | 0.23[5] | 0.09–0.41[5] |
| Duration of illness (days) | 07 [41] | 3–10 [Assumption] |
| Daly weight | 0.2 [41] | 0.061 to 0.281[42] |
| Life Expectancy, (years) | 70 [64] | 65 to75 [Assumptions] |
| Outpatient cost for provider (US $) | 5.48 [44] | 2.26 to 23.65 [44] |
| Outpatient cost for households (US $) | 16.64 [44] | 9.14 to 37.99 [44] |
| Inpatient cost for provider (US $) | 30.26 [44] | 15.64 to137.87 [44] |
| Inpatient cost for households (US $) | 32.24 [44] | 26.99 to 288.79[44] |
| Vaccine purchasing cost per dose (US $) | 0.16 [21] | 0.1 to 5 [23,24,26] |
| Vaccine delivery cost per dose (US $) | 0.835 [43] | 0.5 to 1 [Assumption] |
| Vaccine recipient cost | 0.02 [43] | 0.01 to 0.1 [Assumption] |
| Discount rate (%) | 3% [65,66] | 1 to 10% [63] |
| GDP Threshold for DALYs * | ||
| Very cost effective (per capita GDP**) | (US $) 1,466 | |
| Cost effective (3* per capita GDP) | (US $) 4,398 |
(*World Health Organization guideline
** Bangladesh Bank 2016)