Table 2. Patient clinical characteristics stratified by antipsychotic medication status.
| EOP patients | EOP patients | Statistics patient-level | |
|---|---|---|---|
| Off AP at scan | On AP at scan | ||
| N = 11 | N = 11 | ||
| Sex, female N (%) | 6 (54.5) | 9 (81.8) | FET, p = 0.361 |
| Age Scan (y) | 15.94 ± 1.00 | 17.44 ± 0.65 | t-test, p < 0.001 |
| Range | 14.53–17.25 | 16.53–18.25 | |
| Handedness, left N (%) | 1 (10.0) | 1 (10.0) | FET, p = 1.000 |
| BMI (kg/m2) | 19.20 [17.40, 22.90] | 20.55 [18.93, 25.43] | KW, p = 0.457 |
| Range | 15.4–28.7 | 16.3–35.4 | |
| Missing N (%) | 0 | 3 (27.3) | |
| CGAS | 46.00 ± 8.00 | 43.91 ± 9.38 | t-test, p = 0.580 |
| Range | 34–59 | 32–58 | |
| MFQ | 30.82 ± 12.60 | 27.10 ± 13.39 | t-test, p = 0.520 |
| Range | 5–52 | 8–49 | |
| Missing N (%) | 0 | 1 (9.1) | |
| PANSS | |||
| positive | 19.09 ± 3.83 | 17.18 ± 3.84 | t-test, p = 0.257 |
| Range | 12–25 | 13–26 | |
| negative | 22.09 ± 7.13 | 18.27 ± 6.96 | t-test, p = 0.218 |
| Range | 9–32 | 7–32 | |
| general | 38.73 ± 8.44 | 36.27 ± 7.89 | t-test, p = 0.489 |
| Range | 28–54 | 24–52 | |
| Age of Onset (y) | 14.39 ± 1.92 | 14.83 ± 2.07 | t-test, p = 0.614 |
| Range | 10–16 | 12–17.6 | |
| DUP (w) | 36.00 [23.00, 82.00] | 12.00 [8.00, 18.00] | KW, p = 0.005 |
| Range | 14–227 | 3–125 | |
| DUI (y) | 0.75 [0.66, 1.79] | 1.76 [0.64, 4.52] | KW, p = 0.375 |
| Range | 0.47–4.53 | 0.33–5.97 | |
| Diagnosis | FET, p = 1.000 | ||
| SCZ | 7 | 7 | |
| SCA | 1 | 0 | |
| NOS | 3 | 4 | |
| Antipsychotics | |||
| Aripiprazole | 5 | ||
| Risperidone | 3 | ||
| Quetiapine | 3 | ||
| CPZ | |||
| current | 272.3 ± 140.83 | ||
| Range | 151.52–559.44 | ||
| cumulative (AP-naïve, N = 9) | 0.08 ± 0.28 | 21.6 ± 19.13 | |
| Range | 0–0.92 | 1.69–59.28 | |
| Cannabis use, yes N (%) | 3 (27.3) | 4 (36.4) | FET, p = 1.000 |
| Alcohol use, yes N (%) | 4 (36.4) | 8 (72.7) | FET, p = 0.198 |
*normally distributed data as mean ± standard deviation, non-normal distributed data in median [interquartile range], AP = antipsychotics, N = number of participants, m = male, f = female, y = years, r = right, l = left, IQ = Intelligence Quotient, BMI = Body Mass Index, CGAS = Children’s Global Assessment Scale, MFQ = Mood and Feelings Questionnaire, PANSS = Positive and Negative Symptom Scale, DUP = Duration of Untreated Psychosis, DUI = Duration of illness, SCZ = schizophrenia, SCA = schizoaffective, NOS = psychosis, not other specified, CPZ = chlorpromazine equivalent, KW = Kruskal-Wallis Test, FET = Fisher’s Exact Test.