Table 1. Mutation rate in predicted structural regions.

Region	Whole Protein	Full Active Site	N-term PLP	H-interface
Total Residues	1020	30	20	17
# Mutated	213	10	6	6
Residue Mutation Rate	0.209	0.333	0.300	0.353
p-value (Region rate > whole protein rate)	N/A	0.08	0.22	0.12