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. 2020 May 18;16(5):e1007871. doi: 10.1371/journal.pcbi.1007871

Table 10. Trained parameter weights.

Parameters Unweighted Homozygous Trained Heterozygous Trained
Stability (Stabilizing) 1.0 -1.20 0.69
Stability (Destabilizing) 1.0 -0.95 0.94
Conservation of Residue 1.0 3.43 1.30
Conservation of Substitution -1.0 -3.97 -2.35
Helix 1.0 2.96 2.78
Sheet 1.0 -0.26 4.18
C-term 1.0 2.56 1.50
Active Site 1.0 2.48 3.92
Active Region 1.0 0.00 -5.74
N-term PLP 1.0 3.00 0.94
H-interface 1.0 2.55 -0.43
Dimerization Interface 1.0 -2.48 -0.62
Δ Polarity 1.0 -0.82 -2.06
Δ Charge 1.0 0.57 1.61
Δ Aromaticity 1.0 4.62 -0.32
Δ Proline 1.0 2.59 2.14
Δ Codon availability 1.0 0.23 0.40
Δ Size 1.0 -1.26 1.34