Table 2:
HCV Seropositive Donors Corresponding to Recipients in Table 1
| Donor number | Donor age/sex | Donor race | Donor blood type | Donor HCV NAT | PHS increased risk organ | Donor liver pathology | |||
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | Fibrosis | Steatosis | Iron | ||||||
| 1 | 37/M | Caucasian | O | positive | Yes | Mild, portal, chronic | None significant | None significant | None significant |
| 2† | 40/M | Caucasian | O | positive | Yes | N/A | N/A | N/A | N/A |
| 3 | 57/F | Caucasian | O | positive | No | Mild, portal, chronic | None significant | Mild macrovesicular (<5%) | Patchy, mild, hepatocellular distribution |
| 4 | 46/M | Latino | O | positive | Yes | None significant | None significant | None significant | None significant |
| 5 | 42/F | Black | A | positive | Yes | Moderate, portal, chronic. Multiple portal non-caseating granulomata with giant cells. | Moderate, periportal | Moderate macrovesicular (40%) | Mild increase in reticuloendothelial cells and hepatocytes |
| 6 | 57/M | Black | O | positive | No | Moderate, chronic, portal. | Moderate, portal | Large droplet macrovesicular (<5%), small droplet | Increased iron stores noted in reticuloendothelial cells |
| 7 | 33/M | Caucasian | A | positive | Yes | Mild, portal, chronic | None significant | Large droplet (25%) and small droplet (30%) macrovesicular | Mild hepatocellular and reticuloendothelial stainable iron. |
| 8 | 20/F | Caucasian | A | positive | Yes | Moderate, portal, chronic | Moderate, periportal | None significant | None significant |
| 9 | 49/F | Hispanic | O | positive | Yes | Mild, portal, chronic | Mild, portal | Severe small droplet (90%), mild large droplet (<5%) | None significant |
| 10 | 20/F | Caucasian | O | positive | Yes | N/A | N/A | N/A | N/A |
| 11 | 22/M | Caucasian | O | positive | Yes | None significant | None significant | Small droplet macrovesicular (70%), minimal large droplet macrovesicular (<5%) | None significant |
| 12 | 23/F | Caucasian | O | positive | Yes | Mild, portal, chronic | None significant | Small droplet macrovesicular (20%), minimal large droplet macrovesicular (<5%) | None significant |
| 13 | 56/M | Hispanic | O | positive | No | Mild to moderate, portal, chronic | Minimal fibrosis | None significant | None significant |
| 14 | 49/M | Caucasian | O | positive | Yes | Mild, portal, chronic | Mild, periportal | Small droplet microvesicular (5%) | None significant |
| 15 | 50/F | Black | A | positive | No | Mild, portal, chronic. Minimal interface activity. | None significant | None significant | None significant |
| 16 | 28/M | Caucasian | O | positive | Yes | Mild, portal, chronic | Mild, periportal | Small droplet macrovesicular (10%) | None significant |
| 17 | 32/F | Caucasian | B | positive | Yes | Mild, portal, chronic | None significant | Moderate small droplet macrovesicular (60%) | None significant |
| 18 | 34/F | Caucasian | B | positive | Yes | Mild, portal, chronic | Mild to focal moderate periportal | Small droplet macrovesicular (80%) | None significant |
| 19 | 60/M | Black | O | positive | Yes | Mild, chronic, portal | Moderate portal fibrosis. Rare bridging fibrosis. | Minimal (<5%) | None significant |
| 20 | 30/M | Hispanic | O | positive | Yes | Mild, lobular and portal | None significant | None significant | N/A |
| 21‡ | 55/F | Caucasian | O | negative | No | N/A | N/A | N/A | N/A |
| 22 | 27/F | Caucasian | O | negative | Yes | Mild, portal, chronic | None significant | Severe, diffuse, small droplet (100%) | None significant |
| 23 | 41/M | Caucasian | A | negative | Yes | None significant | Mild, pericellular | Mild | None significant |
| 24 | 68/F | Caucasian | A | negative | No | Moderate lobular and mild portal, mixed acute and chronic | None significant | Large droplet (10%) and small droplet (10%) macrovesicular | None significant |
| 25 | 22/M | Black | A | negative | Yes | Mild, portal, mixed acute and chronic | None significant | Small droplet macrovascular (60%) | Mild increase in hepatocytes and Kupffer cells |
| 26 | 58/M | Caucasian | A | negative | No | None significant | None significant | None significant (<5%) | Mild, intrahepatocyte |
†
Donor liver was sampled but there was no liver tissue identified on pathology. The sample obtained only revealed fibroadipose tissue and peribiliary glands.
‡
Recipient died a week after transplant and biopsy was not obtained intraoperatively during transplant.
Abbreviations: female (F), hepatitis C virus (HCV), male (M), not available (N/A), nucleic acid testing (NAT), Periodic Acid-Schiff/Diastase (PAS/D), Public Health Service (PHS)