Table 1.
Characteristics of spironolactone responders and non-responders in the total population
| Variable | N | Non-responders (n=449) |
Responders (n=1034) |
P value |
| Age, years | 1483 | 63.67±13.18 | 64.28±12.63 | 0.33 |
| Female, n (%) | 1483 | 215 (47.9%) | 532 (51.5%) | 0.21 |
| Black race, n (%) | 1483 | 106 (23.6%) | 263 (25.4%) | 0.46 |
| BMI, kg/m2 | 1358 | 32.20±8.00 | 33.50±8.30 | 0.004 |
| Diagnostic history | ||||
| T2DM, n (%) | 1483 | 236 (52.6%) | 566 (54.7%) | 0.44 |
| CKD3, n (%) | 1483 | 163 (36.3%) | 398 (38.5%) | 0.43 |
| IHD, n (%) | 1483 | 179 (39.9%) | 351 (33.9%) | 0.03 |
| Smoking, n (%) | 1483 | 96 (21.4%) | 211 (20.4%) | 0.67 |
| Baseline measurements | ||||
| SBP, mm Hg | 1483 | 133.20±17.40 | 147.59±18.70 | <0.001 |
| DBP, mm Hg | 1483 | 71.66±11.74 | 79.00±13.08 | <0.001 |
| Serum sodium, mmol/L | 1176 | 138.67±3.22 | 139.25±2.98 | 0.004 |
| Serum potassium, mmol/L | 1177 | 3.95±0.47 | 3.91±0.43 | 0.15 |
| Creatinine, mg/dL | 1184 | 1.12±0.36 | 1.09±0.42 | 0.03 |
| eGFR, mL/min/1.73 m2 | 1382 | 76.73±23.78 | 77.38±20.95 | 0.51 |
| Glucose, mg/dL | 1179 | 125.56±58.56 | 126.98±50.61 | 0.80 |
| HbA1c, % | 538 | 6.91±1.81 | 7.23±3.06 | 0.02 |
| HDL cholesterol, mg/dL | 575 | 47.48±17.97 | 45.53±15.31 | 0.44 |
| LDL cholesterol, mg/dL | 537 | 95.65±39.74 | 98.54±34.72 | 0.41 |
| Triglycerides, mg/dL | 578 | 163.98±111.71 | 169.39±121.20 | 0.85 |
| Difference from baseline following initial spironolactone prescription | ||||
| Serum sodium, mmol/L | 1101 | −0.49±2.63 | −0.95±2.70 | 0.006 |
| Serum potassium, mmol/L | 1104 | 0.13±0.48 | 0.25±0.42 | <0.001 |
| Creatinine, mg/dL | 1108 | 0.02±0.23 | 0.134±0.30 | <0.001 |
| eGFR, mL/min/1.73 m2 | 1254 | −5.22±15.73 | −9.09±15.10 | <0.001 |
| Glucose, mg/dL | 1101 | −0.27±47.82 | −0.37±40.62 | 0.88 |
| HbA1c, % | 284 | −0.25±1.23 | 0.02±1.05 | 0.02 |
| HDL cholesterol, mg/dL | 214 | 0.70±11.51 | −1.36±9.35 | 0.23 |
| LDL cholesterol, mg/dL | 197 | −5.74±32.54 | −7.48±34.94 | 0.77 |
| Triglycerides, mg/dL | 220 | −17.86±107.95 | −19.43±107.16 | 0.91 |
Data are presented as mean±standard deviation for continuous variables and count (%) for categorical variables.
BMI, body mass index; CKD3, chronic kidney disease stage 3; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; IHD, ischaemic heart disease; LDL, low-density lipoprotein; N, number of individuals with the specific measure; SBP, systolic blood pressure; T2DM, type 2 diabetes mellitus.