Table 4.
Subjects’ clinical characteristics by FN3K genotype group; for continuous data, values are mean±SD
| Parameter | A genotype | B genotype | C genotype | E genotype | Others |
| n | 8 | 23 | 11 | 8 | 30 |
| Age (years) | 74±8C, Others | 69±8 | 64±7E | 71±7 | 68±7 |
| Gender, M/F | 4/4 | 8/15 | 7/4 | 5/3 | 17/13 |
| Diabetes duration (years) | 12.4±4.0 | 14.6±4.5 | 15.7±3.9 | 13.1±4.6 | 15.1±4.2 |
| BMI (kg/m2) | 31±5 | 30±6 | 31±5 | 29±4 | 30±5 |
| Waist circumference (cm) | 102±8 | 103±12 | 105±13 | 100±7 | 101±11 |
| Systolic blood pressure (mm Hg) | 135±12 | 135±12 | 138±13 | 139±12 | 137±10 |
| Diastolic blood pressure (mm Hg) | 79±6 | 80±9 | 79±7 | 80±10 | 81±7 |
| DCCT-HbA1c (%) | 7.2±0.7 | 7.6±1.0 | 7.3±0.5 | 7.7±1.1 | 7.2±0.7 |
| IFCC-HbA1c (mmol/mol) | 54.8±7.6 | 59.3±11.3 | 56.0±6.2 | 59.6±14.0 | 54.9±6.9 |
| Total cholesterol (mg/dL) | 181±33 | 180±48 | 158±28 | 188±23 | 179±32 |
| HDL cholesterol (mg/dL) | 56±20 | 57±18 | 55±10 | 47±9 | 50±14 |
| Triglycerides (mg/dL) | 131±57 | 105±47 | 96±36 | 131±41 | 128±61 |
| Microalbuminuria, yes/no | 8/0 | 3/20 | 3/8 | 3/5 | 7/23 |
| Albuminuria (mg/g) | 5±4 | 31±65 | 22±21 | 19±19 | 28±34 |
| Creatininemia (mg/dL) | 0.9±0.3 | 0.8±0.2 | 0.9±0.2 | 1.0±0.2 | 0.8±0.2 |
| Glomerular filtration rate (mL/min) | 77±16 | 84±20 | 82±17 | 71±14 | 89±21E |
| Homocysteine (µmol/L) | 17±3 | 16±5 | 18±8 | 18±7 | 15±5 |
| Vitamin A (µg/dL) | 56±15 | 51±15 | 45±10 | 52±10 | 52±17 |
| Vitamin E (mg/dL) | 1.5±0.3B | 1.3±0.3 | 1.3±0.3 | 1.3±0.2 | 1.3±0.3 |
| Cerebral macroangiopathy, yes/no | 4/4 | 16/7 | 5/6 | 5/3 | 20/10 |
| Coronary heart disease, yes/no | 0/8 | 3/20 | 1/10 | 0/8 | 0/30 |
| Retinopathy, yes/no | 0/8 | 5/18 | 5/6 | 1/7 | 11/19 |
| Peripheral artery disease, yes/no | 0/8 | 3/20 | 1/10 | 2/8 | 5/25 |
Superscript letters indicate significant differences between respective genotype groups.
BMI, body mass index; DCCT-HbA1c, HbA1c according to Diabetes Control and Complications Trial units; F, female; FN3K, fructosamine-3-kinase; HDL, high-density lipoprotein; IFCC-HbA1c, HbA1c according to International Federation of Clinical Chemistry units; M, male.