Table 2.

Estimation of anakinra effect on the composite of invasive mechanical ventilation in the ICU or death, after adjustment for potential confounding factors, using a multivariable Cox proportional hazards model

	Hazard ratio	95% CI	p value
Anakinra group vs historical group	0·22	0·10–0·49	0·0002
Male vs female	1·34	0·69–2·62	0·38
Symptom duration >7 days vs ≤7 days	1·12	0·51–2·43	0·78
Body-mass index (per kg/m2)	0·99	0·94–1·05	0·75
Number of comorbidities ≥2 vs 0–1	0·82	0·41–1·66	0·58
Hydroxychloroquine: treated vs untreated	1·35	0·57–3·17	0·50
Azithromycin: treated vs untreated	0·82	0·34–1·99	0·66

ICU=intensive care unit.