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. 2020 May 29;6(22):eaba0754. doi: 10.1126/sciadv.aba0754

Fig. 3. In vitro immunogenicity of polymer-uricase conjugates.

Fig. 3

(A) DC 2.4 dendritic cells were incubated with native uricase, MPC-uricase, NZPS-uricase, or ZPS-uricase conjugates for 72 hours and stained for flow cytometry. (B) Summary of the percentage of DCs that maintained an immature status (CD40− CD80−). (C) The secretion of TGF-β into the supernatant was detected by an ELISA kit. Statistical significance was determined using Student’s t test. *P < 0.05 and ***P < 0.001. Data are represented as mean ± SEM.