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. 2020 May 29;6(22):eaaz3865. doi: 10.1126/sciadv.aaz3865

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Fig. 4 — (A) Heat map of DEGs (FDR < 0.1 and absolute log₂ fold change > 0.2) in CD4⁺ cells isolated from the spleen of 6-week-old Pcbp1^+/+Cd4-Cre (n = 4) and Pcbp1^fl/flCd4-Cre (n = 4) mice. (B) Volcano plot showing differential gene expression in mice. (C) Enrichment of DEGs (FDR < 0.05) in mice for biological process GO terms. GTPases, guanosine triphosphatases. (D) Heat map of up-regulated T_reg cell signature and down-regulated effector T cell signature genes (FDR < 0.05) in Pcbp1^+/+Cd4-Cre (n = 4) and Pcbp1^fl/flCd4-Cre (n = 4) mice.