Figure 9. A summary of the migratory movement of neutrophils in Sema3f knockdown and overexpression models of acute lung injury.

Neutrophil-specific KO of Sema3f increased neutrophil transit through the airways and led to more rapid clearance of neutrophils from the alveolar space, resulting in faster resolution. In contrast, overexpression of Sema3f in the airspaces caused neutrophil retention and delayed inflammation resolution.