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. 2020 May 4;130(6):2953–2965. doi: 10.1172/JCI123159

Figure 7. SIRT2’s protection of mice from CIPN is dependent on NER function.

Figure 7

(A) Cisplatin and spironolactone (SP) treatment regimen for both Sirt2-KI and Sirt2-KO mice. Both strains of mice received the same treatments: saline, cisplatin alone, SP alone, or both cisplatin and SP. Response of (B) Sirt2-KI mice and (D) Sirt2-KO mice to mechanical stimulation, as measured by von Frey tests, is shown as relative paw-withdrawal threshold (RPWT). Response of the same Sirt2-KI mice (C) and Sirt2-KO mice (E) to thermal stimulation, as measured by hot plate tests, is shown as relative hot plate latency (RHPL). Varying sample sizes were due to the death of some mice from treatment toxicity. Statistical significance was assessed using 1-way ANOVA with Dunnett’s correction (B–E). *P < 0.05; **P < 0.01; ***P < 0.001.