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. 2020 May 4;130(6):2992–3004. doi: 10.1172/JCI128073

Figure 2. Hepatocyte-specific deletion of Slug protects against liver steatosis in obesity.

Figure 2

(A–E) SlugΔhep and Slugfl/fl mice were fed a HFD for 11 weeks. (A) Growth curves (n = 11 per group). (B) Liver size and weight. Male: n = 9 per group; female: n = 10 per group. (C) Reprehensive liver sections (n = 3–9 mice per group). Scale bar: 100 μm. (D) Liver TAG levels (normalized to liver weight). Male: n = 9 per group; female: n = 6 per group. (E) Overnight fasting plasma TAG levels in male (n = 9 per group). (F–J) Slugfl/fl ob/ob males were transduced with GFP or Cre adenoviral vectors for 3 weeks. (F) Liver extracts were immunoblotted with antibodies against Slug and α-tubulin. (G) Growth curves (n = 6 per group). (H) Representative liver sections (3 pairs). Scale bar: 100 μm. (I) Liver TAG levels (normalized to liver weight). GFP: n = 6; Cre: n = 5. Data are presented as mean ± SEM. *P < 0.05, 2-tailed Student’s t test.