Figure 4. Ablation of hepatic Slug suppresses the hepatic lipogenic program.

Slug^Δhep and Slug^fl/fl males were fed a HFD for 11 weeks. (A–C) Affymetrix analysis (n = 6 per group). (A) Gene ontology analysis. (B) Volcano plots. (C) Heatmaps. (D) Liver extracts were immunoblotted with the indicated antibodies. Arrow indicates the mature form of Srepb1c. (E) Liver mRNA abundance (normalized to 36B4 levels). Slug^fl/fl: n = 7; Slug^Δhep: n = 9. Data are presented as mean ± SEM. *P < 0.05, 2-tailed Student’s t test.