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. 2020 Apr 27;130(6):2903–2919. doi: 10.1172/JCI132583

Figure 1. Early and intense immunological pressure against HSV-2 replication within genital microenvironments.

Figure 1

(A) Three HSV-2 shedding episodes with typical characteristics, including rapid time to first peak viral load and rapid viral clearance. Red circles indicate symptomatic time points. (B–D) Analysis of 83 shedding episodes derived from every 6-hour genital sampling. Box plots with IQR (box) and 1.5 × IQR (whiskers). Categorization according to duration: short, under 24 hours (n = 51); medium, 24 to 48 hours (n = 13); and long, over 48 hours (n = 19). (B) Variable first peak viral loads and (C) durations across episodes, with most episodes eliminated in fewer than 48 hours. (D) Uniform occurrence of first peak viral load within the first 20 hours of HSV-2 detection. (E) Correlation of time to first peak viral load with peak episode viral load (Spearman’s = 0.434, P < 0.001). (F) Correlation of time to first peak viral load with episode duration (Spearman’s = 0.534, P < 0.001). (B–F) Red dots indicate symptomatic episodes, which tend to be longer and associated with higher first peak viral loads.