Figure 4. B cell–restricted c-Rel expression in c-Rel–knockout mice fully rescues GC reactions and class switching.

(A) Representative flow cytometry plots of GCB cells (B220⁺CD95^hiCD38^lo) and plasma cells (PC, B220^loCD138⁺). Displayed numbers are median percentages (n = 5). (B–D) GCB cell numbers (B); plasma cell numbers and percentages of IgG1-expressing plasma cells (C); and Tfh cell (TCRβ⁺CD4⁺CD8^–CXCR5^hiPD-1^hiICOS^hi) numbers (D). Individual data points obtained in 3 independent experiments are plotted. Bars and numbers below graphs are median values. *P ≤ 0.05, **P ≤ 0.01, Mann-Whitney test. SPL, spleen; PP, Peyer’s patches.