Figure 1. Plasma glucose, insulin, and C-peptide responses to glucose ingestion.

Plasma glucose, insulin, and C-peptide concentrations before and over a 3-hour period after ingesting a 75-g glucose drink (A, C, and E), and plasma glucose, insulin, and C-peptide 3-hour concentration AUC values (B, D, and F) in the lean-normal (NL), obese-NL, and obese-NAFLD groups. White, gray, and black circles in A, C, and E represent the lean-NL (n = 14), obese-NL (n = 24), and obese-NAFLD (n = 22) groups, respectively. Values in B, D, and F represent the mean ± SEM. P values were determined by 1-way ANOVA with post hoc testing to identify significant mean differences between groups when appropriate. *P < 0.05, value significantly different from the lean-NL value; ^†P < 0.05, value significantly different from the obese-NL value.