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. 2020 May 11;130(6):3151–3157. doi: 10.1172/JCI133159

Figure 3. Skin-directed Klk6 overexpression leads to debilitating joint inflammation and bony abnormalities consistent with psoriatic arthritis (PsA).

Figure 3

(A) Gross images of control and Klk6+ transgenic forelimbs. (B) Curvature of control and Klk6+ spines visualized by micro-computed tomography (micro-CT). Data are representative of 6 animals per group. (C) Pelvic joints of control and Klk6+ mice visualized by micro-CT. Upper panels, sacroiliac (SI) joint; lower panels, pubic symphysis. Arrows, distortion of joint space in SI joints and bony erosions in pubic symphysis. Data are representative of 6 animals per group. SI joints are magnified in Figure 4B. (D) Vertebral body bone density as visualized by brightness (higher density) on micro-CT. (E) H&E staining of control and Klk6+ spine sections. Rightmost panel, misshapen vertebra at level of gross kyphosis. Data are representative of 3 animals. Scale bar: 100 μm. (F) H&E staining of Klk6+ paw sections showing synovial inflammation (black arrows) and enthesitis (white arrows). Arrowheads, bony erosions. Data are representative of 5 animals. Scale bar: 200 μm.