Figure 3. The TB epigenetic landscape is similar to LCMV-induced immune exhaustion.

(A) DNA hypermethylation of genes in CD3⁺CD8⁺ CTLs in TB patients (green), and that reported by Ghoneim et al. (10) (red) and Sen et al. (4) (blue). (B) Genes and GO pathways of CD8⁺ CTLs with DNA hypermethylation for patients with TB from this cohort were compared with genes with DNA hypermethylation, reported by Ghoneim et al. (10), and ChARs induced by chronic LCMV–induced immune exhaustion, reported by Sen et al. (4).