Table 1.

Demographic and clinical characteristics of patients with or without MACE at 5 years and of patients with or without angina at 1 year

	Major Adverse Cardiovascular Events at 5 years			Any Angina at 1 year*
	Yes	No	P-value	Yes	No	P-value
	n=346	n=1554		n=310	n=1353
Assigned to CABG arm	146 (42.2%)	801 (51.5%)	0.001	134 (43.2%)	677 (50.0%)	0.030
Age (y)	64.9 ± 9.7	62.7 ± 8.9	< 0.001	62.2 ± 9.1	63.1 ± 8.9	0.107
Age groups			< 0.001			0.214
< 50	22 (6.4%)	122 (7.9%)		28 (9.0%)	98 (7.2%)
50–59	80 (23.1%)	466 (30.0%)		97 (31.3%)	383 (28.3%)
60–69	124 (35.8%)	617 (39.7%)		108 (34.8%)	555 (41.0%)
>=70	120 (34.7%)	349 (22.5%)		77 (24.8%)	317 (23.4%)
Male	243 (70.2%)	1113 (71.6%)	0.604	201 (64.8%)	999 (73.8%)	0.001
White race	269 (77.7%)	1182 (76.1%)	0.517	247 (79.7%)	1024 (75.7%)	0.135
Body mass index (kg/m2)	29.5 ± 5.7	29.8 ± 5.	0.306	30.0 ± 5.7	29.7 ± 5.2	0.347
History of smoking	65 (18.8%)	233 (15.0%)	0.027	51 (16.5%)	207 (15.3%)	0.436
Prior myocardial infarction	106 (30.6%)	381 (24.5%)	0.018	70 (22.6%)	345 (25.5%)	0.284
Prior cerebrovascular event	24 (6.9%)	41 (2.6%)	< 0.001	12 (3.9%)	39 (2.9%)	0.362
History of peripheral vascular disease	35 (12.5%)	161 (9.9%)	0.201	27 (8.7%)	141 (10.4%)	0.367
Chronic lung disease	21 (6.1%)	62 (4.0%)	0.086	10 (3.2%)	55 (4.1%)	0.491
Recent acute coronary syndrome	121 (35.0%)	462 (29.7%)	0.055	84 (27.1%)	422 (31.2%)	0.157
Three vessel disease	298 (87.1%)	1275 (82.5%)	0.038	254 (81.9%)	1121 (83.4%)	0.532
On insulin	148 (42.8%)	467 (30.1%)	< 0.001	109 (35.2%)	410 (30.3%)	0.095
LVEF (%)	55.8 ± 13.1	59.0 ± 11.2	< 0.001	59.9 ± 11.4	58.7 ± 11.3	0.090
Hemoglobin (g/dL)	13.3 ± 1.9	13.8 ± 1.6	< 0.001	13.5 ± 1.7	13.8 ± 1.6	0.006
Hemoglobin A1C < 7 g/dL	99 (31.4%)	531 (37.0%)	0.060	101 (36.7%)	465 (36.7%)	0.986
eGFR MDRD, mL/min/1.73 m2	63.6 ± 19.8	70.9 ± 17.4	< 0.001	69.1 ± 17.6	70.6 ± 17.8	0.176
Euroscore	3.4 ± 3.0	2.5 ± 2.3	< 0.001	2.5 ± 2.1	2.6 ± 2.3	0.606
SYNTAX score			0.006			0.399
Mean	27.3 ± 8.6	25.9 ± 8.6		25.8 ± 8.4	26.3 ± 8.6
Median (interquartile range)	26.0 (21.0, 32.0)	26.0 (19.8, 31.0)		26.0 (19.0, 31.0)	26.0 (20.0, 31.5)
SYNTAX score >22	238 (68.8%)	987 (63.5%)	0.063	198 (63.9%)	880 (65.0%)	0.697
Number of antianginal medications	1.5 ± 0.9	1.5 ± 0.9	0.489	1.5 ± 0.9	1.4 ± 0.9	0.825
Angina frequency			0.177			< 0.001
Daily/Weekly	96 (34.5%)	593 (37.0%)		156 (50.8%)	446 (33.1%)
Monthly	127 (45.7%)	639 (39.9%)		116 (37.8%)	556 (41.2%)
No Angina	55 (19.8%)	369 (23.0%)		35 (11.4%)	346 (25.7%)
SAQ Angina Frequency	72.0 ± 23.8	71.0 ± 25.1	0.491	62.3 ± 26.2	73.4 ± 24.2	< 0.001

^*Data on angina frequency at 1 year was missing in 237 patients