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. Author manuscript; available in PMC: 2020 Jun 6.
Published in final edited form as: Pharmacogenomics J. 2019 Dec 6;20(3):482–493. doi: 10.1038/s41397-019-0132-y

Table 1.

Baseline characteristics of 21 participating cohorts of European and African ancestry. Seventeen cohorts were used for loop diuretic analysis.

Ancestry Study N Loop
Exposed
Subjects
Thiazide
Exposed
Subjects
TG
(Mean & SD)
European AGES 1,677 153 466 1.17 (0.57)
ARIC 8,881 179 1,179 1.55 (1.03)
CHS 3,174 218 838 1.58 (0.85)
FHS 7,068 163 567 1.48 (1.17)
Health ABC 1,828 130 329 1.73 (1.00)
HVH1 440 51 167 2.25 (1.29)
HVH2 192 21 80 2.36 (1.96)
HyperGEN 1,187 44 196 1.87 (1.31)
MESA 2,359 NA 563 1.49 (1.02)
PROSPER 4,592 618 1,402 1.52 (0.70)
RS1 3,421 269 405 1.38 (0.61)
RS2 2,096 86 147 1.40 (0.64)
WHI CT GARNET Baseline 1,222 24 142 1.65 (0.86)
WHI CT GARNET Core 861 15 78 1.66 (0.81)
African ARIC 2,119 45 655 1.26 (0.86)
CHS 709 104 250 1.30 (0.71)
HyperGEN 1,110 86 278 1.17 (0.77)
JHS 1,500 91 381 1.20 (0.96)
WHI CT SHARe Baseline 3,636 150 752 1.26 (0.76)
WHI CT SHARe Core 801 34 176 1.35 (0.64)
WHI OS SHARe Baseline 3,628 206 843 1.27 (0.77)

BMI, body mass index (kg/m2); DBP, diastolic blood pressure (mmHg); SBP, systolic blood pressure (mmHg); TG, triglycerides (mmol/L).