. Author manuscript; available in PMC: 2020 Jun 6.

Published in final edited form as: Pharmacogenomics J. 2019 Dec 6;20(3):482–493. doi: 10.1038/s41397-019-0132-y

Table 2.

SNVs with genome-wide significant (with P < 5×10⁻⁸ from METAL or Bayes factor >10⁶ from MANTRA) SNV-loop diuretic interactions on triglyceride concentrations identified from European-ancestry, African-ancestry, and trans-ancestry analyses.

Marker	Chr	Position	Alleles	European Ancestry				African Ancestry				Trans Ancestry				Mantra	Neighboring Genes

				Freq	P	Effect	SE	Freq	P	Effect	SE	Freq	P	Effect	SE	log₁₀BF

rs1463034	1	103,227,805	t/c	0.92	1.91E-09	0.0126	0.0003	0.59	4.40E-01	0.0111	0.0003	0.83	2.27E-06	0.0121	0.0001	5.54	*COL11A1*
rs1870958	1	103,229,744	t/g	0.92	2.57E-09	0.0126	0.0003	0.59	5.00E-01	0.0111	0.0003	0.82	4.01E-06	0.0121	0.0001	6.53
rs2786125	1	103,235,061	a/g	0.06	1.94E-08	0.0100	0.0002	0.31	4.37E-01	0.0115	0.0003	0.14	2.18E-05	0.0105	0.0002	5.68
rs2622870	1	103,236,564	t/g	0.94	1.98E-08	0.0127	0.0003	0.69	3.40E-01	0.0110	0.0003	0.87	2.14E-05	0.0122	0.0002	6.14
rs2622874	1	103,239,505	a/c	0.06	1.93E-08	0.0100	0.0002	0.31	3.26E-01	0.0116	0.0003	0.13	2.31E-05	0.0104	0.0002	6.77

rs7607797	2	117,944,672	t/c	0.97	3.60E-08	0.0127	0.0003	0.66	4.62E-01	0.0111	0.0003	0.86	6.88E-05	0.0121	0.0002	3.51	DDX18

rs7002454	8	104,347,955	t/c	0.95	8.78E-05	0.0124	0.0002	0.87	3.58E-02	0.0122	0.0005	0.93	1.10E-05	0.0124	0.0002	6.10	*BAALC* / FZD6
rs6985929	8	104,348,009	a/g	0.95	8.86E-05	0.0124	0.0002	0.87	3.29E-02	0.0124	0.0005	0.93	1.02E-05	0.0124	0.0002	6.17	*BAALC* / FZD6

rs10508671	10	24,574,062	t/c	0.03	9.43E-07	0.0102	0.0002	0.25	2.12E-03	0.0103	0.0003	0.11	1.07E-08	0.0102	0.0002	6.23	*KIAA1217* / MIR603 / ARHGAP21
rs10508672	10	24,574,441	a/g	0.03	9.52E-07	0.0102	0.0002	0.24	2.32E-03	0.0103	0.0003	0.11	1.18E-08	0.0102	0.0002	6.20	*KIAA1217* / MIR603 / ARHGAP21

rs3852940	20	6,165,600	a/g	0.79	6.78E-01	0.0112	0.0002	0.70	1.18E-08	0.0132	0.0004	0.77	1.09E-02	0.0116	0.0001	5.73	CRLS1 / LRRN4 / FERMT1 / CASC20 / BMP2
rs6054016	20	6,174,368	t/c	0.06	6.06E-01	0.0114	0.0003	0.19	4.06E-10	0.0092	0.0003	0.10	2.15E-03	0.0103	0.0002	7.84
rs6054018	20	6,175,236	t/g	0.94	6.12E-01	0.0112	0.0003	0.80	1.70E-10	0.0139	0.0004	0.90	1.83E-03	0.0124	0.0002	7.60
rs8120588	20	6,178,849	t/c	0.94	6.24E-01	0.0112	0.0003	0.81	3.75E-10	0.0139	0.0004	0.90	1.88E-03	0.0124	0.0002	7.99
rs7348828	20	6,182,498	a/g	0.94	6.38E-01	0.0112	0.0003	0.81	3.56E-10	0.0139	0.0004	0.90	1.75E-03	0.0124	0.0002	6.60
rs8122198	20	6,186,686	t/c	0.94	8.99E-01	0.0113	0.0003	0.85	9.53E-09	0.0141	0.0006	0.91	2.46E-03	0.0122	0.0002	6.29
rs6054037	20	6,187,877	c/g	0.94	8.69E-01	0.0113	0.0003	0.85	9.94E-09	0.0141	0.0006	0.91	2.73E-03	0.0122	0.0002	6.43
rs6038400	20	6,188,201	a/c	0.06	8.66E-01	0.0113	0.0003	0.15	1.03E-08	0.0091	0.0004	0.09	2.78E-03	0.0104	0.0002	5.08
rs3852942	20	6,192,559	a/g	0.06	8.71E-01	0.0113	0.0003	0.17	3.36E-08	0.0093	0.0003	0.10	3.46E-03	0.0104	0.0002	4.53

Covariates included in the analysis: age, sex, BMI, principal components, and additional cohort-specific covariates (if any). Abbreviations: Chr, chromosome, Freq, frequency of allele 1. Bolded genes include intragenic SNVs. Bolded P-values and MANTRA log₁₀BF identify values that are genome-wide significant. Units for Effect (SE) is mmol/L.