Table 3.

Association of COMT haplotypes with analgesic response from morphine and butorphanol in different pain modalities. SNP sequence in the haplotype: rs6269_rs4633_ rs4818_rs4680. *Nominal P<0.05.

Morphine
	Heat pain threshold		Heat pain tolerance		Ischemic pain threshold		Ischemic pain tolerance		Pressure pain, masseter		Pressure pain, trapezius		Pressure pain, ulna
Haplotype	BETA	P	BETA	P	BETA	P	BETA	P	BETA	P	BETA	P	BETA	P
A_T_C_A	0.083	0.72	0.017	0.90	−16.50	0.042*	18.50	0.28	−0.010	0.85	0.11	0.37	−0.043	0.75
G_C_G_G	−0.18	0.49	−0.15	0.32	13.30	0.13	−21.90	0.22	−0.038	0.51	−0.25	0.052	−0.10	0.47
A_C_C_G	0.37	0.33	0.33	0.15	0.056	1.00	4.66	0.86	0.14	0.11	0.20	0.31	0.26	0.24
G_C_C_G	−0.29	0.80	0.00	1.00	6.86	0.87	−62.00	0.40	−0.12	0.67	−0.19	0.76	−0.05	0.94
Butorphanol
A_T_C_A	−0.074	0.78	0.0090	0.96	−15.60	0.22	11.30	0.69	−0.0033	0.96	0.037	0.81	0.29	0.052
G_C_G_G	0.031	0.91	0.11	0.54	−4.72	0.74	−42.30	0.17	0.03	0.67	−0.25	0.15	−0.34	0.039*
A_C_C_G	−0.33	0.45	−0.37	0.15	26.50	0.19	43.70	0.29	−0.04	0.72	0.30	0.22	−0.10	0.69
G_C_C_G	1.05	0.42	0.19	0.81	26.00	0.68	−88.10	0.48	0.11	0.74	0.27	0.73	0.40	0.59