Table 2.
Association between self-reported family history of comorbidities and developing RA, ordered by strength of association
| N (%) | ||||
|---|---|---|---|---|
| Comorbidity | RA Cases (N = 821) | Controls (N = 2455) | Unadjusted OR for RA (95% CI) | Adjusted OR for RA (95% CI)* |
| Rheumatoid arthritis | 272 (36) | 379 (18) | 2.56 (2.12,3.08) | 2.44 (2.02,2.94) |
| HIV | 9 (1) | 11 (0.5) | 2.47 (0.99,5.98) | - |
| Pulmonary fibrosis | 20 (3) | 29 (1) | 2.10 (1.17,3.72) | 2.12 (1.16,3.80) |
| Rheum. autoimmune dz.** | 82 (11) | 143 (7) | 1.84 (1.38,2.44) | 1.89 (1.41,2.52) |
| Autism | 24 (3) | 44 (2) | 1.66 (0.99,2.72) | 1.62 (0.96,2.67) |
| Tuberculosis | 34 (5) | 68 (3) | 1.52 (0.99,2.30) | 1.51 (0.98,2.30) |
| Inflammatory bowel disease | 62 (8) | 129 (6) | 1.49 (1.08,2.03) | 1.45 (1.05,1.98) |
| Celiac disease | 29 (4) | 62 (3) | 1.44 (0.91,2.24) | 1.45 (0.91,2.27) |
| Osteoarthritis | 403 (55) | 1075 (47) | 1.36 (1.15,1.61) | 1.41 (1.19,1.68) |
| Fibromyalgia | 74 (10) | 168 (8) | 1.39 (1.04,1.84) | 1.40 (1.04,1.86) |
| Hyper/hypothyroidism | 206 (28) | 490 (23) | 1.34 (1.11,1.62) | 1.34 (1.10,1.63) |
| Other liver disease | 61 (8) | 137 (6) | 1.36 (0.99,1.85) | 1.29 (0.93,1.77) |
| Obstructive sleep apnea | 205 (28) | 503 (22) | 1.32 (1.09,1.59) | 1.28 (1.05,1.55) |
| Other mental illness | 93 (13) | 222 (10) | 1.29 (0.99,1.66) | 1.24 (0.95,1.61) |
| Migraine headaches | 267 (36) | 703 (32) | 1.22 (1.02,1.45) | 1.20 (1.00,1.43) |
| Asthma | 232 (31) | 607 (27) | 1.20 (1.00,1.44) | 1.20 (0.99,1.44) |
| COPD | 125 (17) | 304 (14) | 1.27 (1.01,1.59) | 1.19 (0.94,1.50) |
| Venous thromboembolism | 125 (17) | 319 (15) | 1.20 (0.95,1.50) | 1.18 (0.94,1.48) |
| Type 2 diabetes | 214 (29) | 723 (32) | 0.85 (0.70,1.01) | 0.81 (0.67,0.97) |
| Parkinson’s disease | 44 (6) | 182 (8) | 0.71 (0.50,0.99) | 0.70 (0.49,0.98) |
CI = confidence interval, COPD = chronic obstructive pulmonary disease, dz = disease, HIV = human immunodeficiency virus, OR = odds ratio, RA = rheumatoid arthritis, rheum. = rheumatologic
*
Adjusting for age, sex, race, BMI, education, smoking (ever vs never). Bold values are statistically significant at p<0.01.
**
Prompted participants with the examples of scleroderma, lupus