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. Author manuscript; available in PMC: 2020 Oct 25.
Published in final edited form as: Oncogene. 2020 Apr 25;39(22):4344–4357. doi: 10.1038/s41388-020-1300-x

Figure 1: AZD7762 treatment abrogates RT induced G2/M Checkpoint.

Figure 1:

Flow cytometry analysis showing the cell cycle distribution by DNA content of A) MCF10A and B) B16-F10 cells by treatment status. Each cell lines had one of four treatment conditions: Untreated, or treated with the CHK1 inhibitor AZD7762, Radiation (RT), or CHK1i+RT. AZD7762 was added 1 hour prior to RT. MCF10A cells underwent 16 Gy of RT and B16-F10 underwent 4 Gy of RT. Cell fixation was performed at 8 hours following radiation for cell cycle analysis. The G2/M population is highlighted within each panel.