Table 1. Clinical and morphological parameters of patients and alteration of stemness gene amplification during NAC.
| Patients# | Amplification of stemness genes | Change during NAC | T | N | Molecularsubtype | Efficiency NAC | Metastasis | MFS, month | |
|---|---|---|---|---|---|---|---|---|---|
| Pretreatment | Postreatment | ||||||||
| A126/3 | 8q16p | no | elimination | 2 | 1 | LumB | pCR | no | 24 |
| B386/2 | 3q10p13q | no | elimination | 2 | 0 | LumB | pCR | no | 35 |
| G265/5 | 7q9p10p19p | no | elimination | 3 | 0 | LumB | pCR | no | 31 |
| I133/4 | 7q8q | no | elimination | 2 | 0 | LumB | pCR | no | 22 |
| Ya134/1 | 8q10p | no | elimination | 2 | 0 | LumB | pCR | no | 32 |
| K467/2 | 8q10p16p | no | elimination | 2 | 1 | LumB | pCR | no | 24 |
| Sh244/4 | 16p | no | elimination | 2 | 1 | LumB | PR | no | 18 |
| B394/2 | 8q10p | no | elimination | 2 | 0 | LumB | PR | no | 35 |
| M483/1 | 8q16p | no | elimination | 2 | 1 | LumB | PR | no | 52 |
| V396/2 | 7q16p | 16p | elimination | 2 | 1 | LumB | PR | no | 113 |
| S577/2 | 3q6p | 3q | elimination | 2 | 0 | LumB | PR | no | 37 |
| S702/2 | 5p8q | 8q | elimination | 2 | 1 | LumB | PR | no | 96 |
| K345/2 | 5p8q16p | no | elimination | 1 | 1 | LumB | PR | no | 97 |
| M366/2 | 3q6p8q | 3q8q | elimination | 2 | 0 | LumB | PR | no | 48 |
| L355/3 | 8q13q16p18 | 3q8q16p | elimination | 2 | 0 | LumB | PR | no | 30 |
| Sh198/2 | 7q10p10q16p | 7q | elimination | 2 | 0 | TNBC | PR | no | 89 |
| L234/2 | 8q9p9q10p16p | 8q | elimination | 2 | 0 | LumB | PR | no | 56 |
| S454/3 | 5p6p8q9q10p16p | no | elimination | 2 | 0 | LumB | PR | no | 66 |
| K677/2 | 5p8q9q10p16p | 8q | elimination | 2 | 1 | LumB | SD | no | 22 |
| D390/2 | 5p8q10p | 5p8q | elimination | 2 | 1 | LumB | SD | no | 24 |
| K187/1 | no | no | no change | 2 | 1 | LumB | PR | no | 28 |
| M187/2 | no | no | no change | 2 | 1 | LumB | PR | no | 98 |
| S667/1 | no | no | no change | 2 | 1 | LumB | PR | no | 26 |
| D121/1 | no | no | no change | 2 | 0 | LumB | PR | no | 32 |
| Sh332/1 | no | no | no change | 2 | 0 | LumB | PR | no | 71 |
| V134/4 | 8q10p | 8q10p | no change | 2 | 0 | LumB | PR | no | 43 |
| J134/2 | 5p8q16p | 5p8q16p | no change | 4 | 0 | LumB | PR | no | 115 |
| Ch341/1 | 5p8q16p | 5p8q16p | no change | 3 | 3 | LumB | PR | no | 21 |
| D256/2 | 5p8q9q10q | 5p8q9q10q | no change | 2 | 1 | LumB | PR | Yes | 19 |
| P167/3 | 6p7q8q9p | 6p7q8q9p | no change | 4 | 1 | TNBC | PR | no | 63 |
| N111/2 | 6p7q8q10p10q16p | 6p7q8q10p10q16p | no change | 2 | 2 | TNBC | PR | no | 32 |
| B278/1 | no | no | no change | 1 | 1 | LumB | SD | no | 130 |
| M289/3 | no | no | no change | 2 | 0 | LumB | SD | no | 73 |
| K544/1 | no | no | no change | 2 | 0 | TNBC | SD | no | 38 |
| G373/2 | 5p | 5p | no change | 2 | 1 | TNBC | SD | no | 98 |
| J259/4 | 8q16p | 8q16p | no change | 2 | 1 | LumB | SD | no | 26 |
| Ch233/3 | 5p7q8q10p16p | 5p7q8q10p16p | no change | 2 | 0 | LumB | SD | no | 41 |
| G178/3 | 3q5p8q | 3q5p8q | no change | 2 | 0 | LumB | SD | Yes | 62 |
| S156/1 | 5p7q16p18q19p | 5p7q16p18q19p | no change | 2 | 2 | LumB | SD | Yes | 24 |
| P244/3 | 8q18q | 6p8q18q | induction | 2 | 0 | LumB | PR | no | 31 |
| B156/5 | 16p | 5p16p | induction | 2 | 1 | LumB | PR | Yes | 25 |
| Yu176/4 | 6p8q | 6p8q13q | induction | 2 | 3 | LumB | PR | Yes | 43 |
| K743/3 | 8q9q13q | 3q6p8q9q13q | induction | 2 | 1 | LumB | PR | Yes | 12 |
| L188/4 | 8q | 8q10p | induction | 2 | 3 | LumB | SD | Yes | 10 |
| K299/2 | 8q16p | 5p8q16p | induction | 2 | 0 | LumB | SD | Yes | 105 |
| R198/4 | 7q9p10p | 5p7q9p10p | induction | 4 | 3 | LumB | SD | Yes | 12 |
| S232/2 | 6p9p10p | 6p7q8q9p10p | induction | 2 | 1 | LumB | SD | Yes | 20 |
| Ch145/1 | 5p7q8q16p | 5p7q10q8q16p | induction | 2 | 0 | LumB | SD | Yes | 23 |
| E106/2 | 8q | 3q16p18q | induction | 2 | 2 | LumB | PD | Yes | 47 |
| S300/3 | 8q | 5p7q8q13q19p | induction | 3 | 3 | TNBC | PD | Yes | 17 |
Abbreviations: MFS, metastasis-free survival; LumB, luminal B breast cancer; TNBC, triple-negative breast cancer; PD, progressive disease; pCR, pathological complete response; PR, partial response; SD, stable disease.