Figure 6. TAK1 changes cytokine expression of THP-1 macrophages without affecting their growth rates.

(A) Tumors isolated from MDA-MB-231 TAK1^WT and TAK1^KO xenografts were profiled for cytokine and chemokine molecular expression. (B) TAK1 does not affect growth of THP-1 macrophages, suggesting macrophages are phenotypically changing their cytokine profiles. (C) TAK1 seems to play a role in cytokine expression, upregulating some and downregulating others. n = 4 ± SEM/WT, n = 4 ± SEM/TAK1^KO group. RFU = Relative fluorescent unit. ^* p < 0.05, ^** p < 0.01, ^*** p < 0.0001, Student’s T test.