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. 2020 May 26;11(21):1942–1952. doi: 10.18632/oncotarget.27600

Table 2. Number of grade 2 & 3 toxicities probably, possibly or definitely attributable to vemurafenib.

Adverse Event Grade 2 Grade 3
Alanine aminotransferase increased 0 1
Alkaline phosphatase increased 1 1
Alopecia 1 0
Anorexia 2 0
Arthralgia 3 0
Aspartate aminotransferase increased 2 0
Blood bilirubin increased 3 1
Bullous dermatitis 1 0
Creatinine increased 2 0
Diarrhea 2 0
Dry skin 3 0
Electrocardiogram QT corrected interval prolonged 0 1
Erythema multiforme 1 0
Erythroderma 1 0
Fatigue 2 0
Fever 1 2
Gastrointestinal disorders - Acid reflux 1 0
Headache 1 0
Hypertension 2 0
Hypophosphatemia 1 0
Investigations - Plantar hyperkeratosis with pain 1 0
Lymphocyte count decreased 2 1
Mucositis oral 1 0
Nausea 1 0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) - keratoacanthomas 0 1
Palmar-plantar erythrodysesthesia syndrome 1 0
Photosensitivity 0 1
Pneumonitis 0 1
Pruritus 1 1
Rash maculo-papular 12 10
Skin and subcutaneous tissue disorders – Dermatitis, heat rash, photoonycholysis 3 0
Skin infection 1 0
Somnolence 1 0
Weight loss 1 0