Table 3.
Rates of patients with adverse events by weight groups (normal weight, overweight, obese) and all patients. MACE is defined as death or nonfatal myocardial infarction or nonfatal stroke.
| Normal weight group treated (n = 26) | Normal weight group untreated control (n = 37) | p value between groups | Overweight group treated (n = 121) | Overweight group untreated control (n = 165) | p value between groups | Obese group treated (n = 281) | Obese group untreated control (n = 193) | p value between groups | ALL Treated (n = 428) | ALL Untreated control (n = 395) | p value between groups | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Deaths | 1 (3.8%) | 3 (8.1%) | NS | 4 (3.3%) | 14 (8.5%) | NS | 18 (6.4%) | 60 (31.1%) | <0.0001 | 23 (5.4%) | 77 (19.5%) | <0.0001 |
| Nonfatal myocardial infarctions | 0 (0%) | 4 (10.8%) | NS | 0 (0%) | 21 (12.7%) | <0.0001 | 0 (0%) | 49 (25.4%) | <0.0001 | 0 (0%) | 74 (18.7%) | <0.0001 |
| Nonfatal strokes | 0 (0%) | 6 (16.2%) | <0.05 | 0 (0%) | 11 (6.7%) | <0.005 | 0 (0%) | 50 (25.9%) | <0.0001 | 0 (0%) | 67 (17.0%) | <0.0001 |
| Prostate cancer | 0 (0%) | 1 (2.7%) | NS | 5 (4.1%) | 15 (9.1%) | NS | 7 (2.5%) | 29 (15.0%) | <0.0001 | 12 (2.8%) | 45 (11.4%) | <0.05 |
| MACE | 1 (3.9%) | 8 (21.6%) | NS | 4 (3.3%) | 38 (23.0%) | <0.0001 | 18 (6.4%) | 98 (50.8) | <0.0001 | 23 (5.4%) | 144 (36.5%) | <0.0001 |
NS non-significant