Fig. 1.

Prevention of memory deficits in ovariectomized female Tg2576 transgenic mice by DHED treatment. Ovariectomized female mice were divided into groups as control (no treatment), vehicle, DHED, or DHED and ICI182780 treatment at the same time for 2 months, then the effects of treatment on spatial learning-memory of AD mice were tested. a Escape time in seconds required for finding the platform. *p < 0.05 vs control or vehicle or DHED+ICI182780. b Frequency of platform crossover. c The percentage of time spent in the four quadrants during 60 s. *p < 0.05 vs control or vehicle or DHED+ICI182780. d Swimming velocity. Four groups of mice were used, n = 10 in each group. Data are presented as mean values ± SEM. ANOVA, *p < 0.05