Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 29;10:8754. doi: 10.1038/s41598-020-65602-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Mutant strains after passage in drug-free medium have low-level resistance, fold change in resistance increases with % MIC. Cells were passaged on drug-free media for 5 days and the MIC to ciprofloxacin was tested. Each strain name (#-#) corresponds to exposure time-ciprofloxacin concentration (% MIC). Fold change (relative to drug-free control) in MIC of ciprofloxacin is plotted against ciprofloxacin treatment concentration (as % MIC) for mutant from (a) 24 hr exposure or (b) 48 hr exposure. Error bars represent the standard deviation of the mean of 3 replicate measurements. A fold change of 1 indicates no change. Drug-free control matched MIC of parental WT cells and conditions with no growth during purification were not plotted. All non-synonymous genetic changes identified in sequencing are shown below strain name. *P value < 0.05.