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. 2020 May 29;10:8754. doi: 10.1038/s41598-020-65602-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutants demonstrate increased multi-drug resistance which increase with concentration and time. MIC of different classes of antibiotic were determined for stable mutants. For 24 and 48 hr exposure mutants, the fold change in MIC relative to drug-free control was measured for 4 different antibiotics, (a) kanamycin (KAN, MIC = 16 ug/ml), (b) chloramphenicol (CHL, MIC = 8ug/ml) (c) ampicillin 1 (AMP, MIC = 8 ug/ml) and (d) tetracycline (TET, MIC = 2ug/ml). Error bars represent the standard deviation of the mean of 3 replicate measurements. A fold change of 1 indicates no change. The MIC of the drug-free control matched the MIC of WT parental cells. Conditions with no growth after exposure were not plotted. All nonsynonymous genomic changes identified in sequencing are shown below mutant name. *P value < 0.05.