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. 2020 May 29;10:8766. doi: 10.1038/s41598-020-65617-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Sagittal contrast-enhanced T1-weighted MRI showing BBB disruption, evident in the area outlined in red. The targets that were within ±1 mm of this image plane are shown, and the brain is segmented with a white contour. (b) Segmentations of the brain and the area with evident BBB disruption for 30 consecutive sessions. The targets are indicated. In most cases, the extent of the BBB disruption was contained within the brain. In a few cases, the disruption reached the brain surface proximal to the transducer. The distance between the average depth of the segmented BBB disruption and the target plane was less than one millimeter in 25/30 sessions.