Table 3.
Measurements and outcomes for the four sonicated volumes.
| Volume 1 | Volume 2 | Volume 3 | Volume 4 | P | |
|---|---|---|---|---|---|
| Acoustic energy (mJ) | 83.7 ± 14.4 | 78.9 ± 14.4 | 63.2 ± 10.7 | 68.5 ± 15.3 | <0.001 |
| Peak Harmonic emission (dB) | 9.2 ± 2.5 | 9.5 ± 1.9 | 10.6 ± 2.1 | 11.6 ± 3.2 | <0.001 |
| Integrated Harmonic emission (dB) | 276.4 ± 2.5 | 290.6 ± 1.9 | 292.8 ± 2.1 | 287.2 ± 3.2 | <0.001 |
| ΔR1 (s−1) | 0.076 ± 0.040 | 0.101 ± 0.037 | 0.051 ± 0.035 | 0.062 ± 0.035 | <0.001 |
| Contrast enhancement (% increase) | 7.3 ± 4.2 | 11.6 ± 5.2 | 7.5 ± 5.6 | 9.6 ± 6.4 | 0.001 |
| Edema at 24 h (N sessions)a | 15/29 | 0/29 | 0/29 | 0/29 | — |
| Edema at 7d (N sessions)b | 2/20 | 0/20 | 0/20 | 0/20 | — |
| BBB disruption at 24 h (N sessions)a | 12/29 | 0/29 | 0/29 | 0/29 | — |
| Petechiae/hemosiderin: N volumes | 4/10 | 2/10 | 4/10 | 2/10 | — |
| Petechiae/hemosiderin: N clusters | 32 | 3 | 48 | 8 | — |
| Petechiae/hemosiderin: max. dimension (µm) | 85.6 ± 61.2 | 48.4 ± 2.2 | 45.4 ± 28.9 | 66.2 ± 33.9 | 0.001 |
| Petechiae/hemosiderin: area (µm2) | 4992 ± 6867 | 1372 ± 76 | 1277 ± 1419 | 2672 ± 2313 | 0.003 |
| Scar: N volumes | 4/10 | 0/10 | 0/10 | 0/10 | — |
| Scar: max. dimension (mm) | 0.50-1.18 | — | — | — | — |
| Scar: area (mm2) | 0.09-0.25 | — | — | — | — |
aNo 24 h MRI in one animal.
bNo 7d MRI after session 3.